SPM Supreme™
WhatToTrustTM Score
12345678910
Designs For Health
Last updated: Jan 17, 2026
A synergistic combination of three specialized pro‑resolving mediators (SPMs) to help support a normal inflammatory response and the body's normal healing process.*
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SPM Supreme™ Ingredients*
We only evaluate bioactive ingredients—the ones that truly contribute to a product's performance. Below is a list of bioactive ingredients found in this product.
For each ingredient, the quantity in parentheses indicates the amount per serving.
Total Omega-3s refers to the combined amount of omega-3 fatty acids—primarily EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid), and sometimes ALA (alpha-linolenic acid)—found in a product. These essential fats are known for supporting heart, brain, and joint health.
Omega-3 EPA and DHA are essential fatty acids found in fish and seafood, necessary for heart health and brain function.
EPA (Eicosapentaenoic Acid) is a long-chain omega-3 fatty acid found in fatty fish and marine oils. It is commonly included in supplements alongside DHA for nutritional support.
Docosahexaenoic Acid (DHA) is an omega-3 fatty acid that is crucial for brain health and development.
Designs for Health Pro-Resolving Mediators (PRMs) include, 18-HEPE, 17-HDHA, and 14-HDHA. PRMs are produced from the enzymatic conversion of essential fatty acids, primarily omega-3 fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are found in fish oil. They can also be derived from omega-6 fatty acids. Their main job is not to suppress the immune response, but to actively "resolve" it.
18-hydroxyicosapentaenoic acid (18-HEPE) is a specific metabolite of eicosapentaenoic acid (EPA), an omega-3 fatty acid found in fish oil. It is a key intermediate molecule in the body's natural process of resolving inflammation.
17-hydroxydocosahexaenoic acid (17-HDHA) is a specialized metabolite of docosahexaenoic acid (DHA), a key omega-3 fatty acid. It serves as a crucial intermediate molecule in the body's active process of resolving inflammation.
14-hydroxydocosahexaenoic acid (14-HDHA) is a specialized lipid mediator derived from the omega-3 fatty acid docosahexaenoic acid (DHA). It is a key intermediate molecule and a crucial pro-resolving mediator (PRM) precursor.
*These product and ingredient description statements have not been evaluated by the Food and Drug Administration (FDA). This product or its ingredients are not intended to diagnose, treat, cure or prevent any disease.
Product description and ingredient list are obtained from the product's brand/company website. Ingredient description is provided by our expert.
WhatToTrustTM scores are based on ingredient quality tests as well as pre-clinical and clinical testing to ensure that a product is scientifically developed and manufactured.
Breakdown of WhatToTrustTM Score for this product
WhatToTrustTM Science Score
2/10
Ingredient Quality Testing (Batch-to-Batch Testing)
Identity and Potency Testing
yes
Purity/Contaminant Testing
yes
Ingredient Validation Testing
Ingredient Validation Pre-clinical Testing (non-Canomiks test)
yes - (Partial. Product website does not mention pre-clinical trial, but some similar ingredients have been tested.)
CanTrust by Canomiks® Ingredient Validation Pre-clinical Testing and Certification
no
Ingredient Clinical Trial/Testing
yes - (Partial. Product website does not mention clinical trial, but some similar ingredients 've been clinically tested.)
Borrowed Science
no
Product Validation Testing
Product Validation Pre-clinical Testing (non-Canomiks test)
no
CanTrust by Canomiks® Product Validation Pre-clinical Testing and Certification
no
Product Clinical Trial/Testing
no
Borrowed Science
no
WhatToTrustTM ScoreHow we calculate WhatToTrustTM Score.
WhatToTrustTM Score
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